PREFORMULATION STUDIES AND PREPERATION OF DITHRANOL LOADED SOLID LIPID NANOPARTICLES

Cytotoxicity of Tamoxifen-Loaded Solid Lipid Nanoparticles

Breast cancer is one the most important health concerns of the modern society (Ferlay et al., 2007). Worldwide, it is estimated that over one million new cases of breast cancer are diagnosed every year, and more than 400 thousands will die from the breast cancer (Coughlin & Ekwueme, 2009) The life-time risk in women contracting breast cancers is estimated to be 1 in 8, which is the highest amon...

Sustained release Curcumin loaded Solid Lipid Nanoparticles.

PURPOSE curcumin is poorly water soluble drug with low bioavailability. Use of lipid systems in lipophilic substances increases solubility and bioavailability of poorly soluble drugs. The aim of this study was to prepare curcumin loaded Solid Lipid Nanoparticles (SLNs) with high loading efficiency, small particle size and prolonged release profile with enhanced antibacterial efficacy. METHODS...

preparation and assessment of piroxicam loaded solid lipid nanoparticles

Stability and antimicrobial effect of amikacin-loaded solid lipid nanoparticles

Solid lipid nanoparticles (SLNs) of amikacin were designed in this study for pulmonary delivery to reduce the dose or its administration intervals leading to reduction of its toxicities especially in long term treatment. Nanoparticles of amikacin were prepared from cholesterol by solvent diffusion technique and homogenization. The size, zeta potential, loading efficiency, and release profile of...

Formulation and Physicochemical Characterization of Lycopene-Loaded Solid Lipid Nanoparticles.

PURPOSE Lycopene belongs to the carotenoids that shows good pharmacological properties including antioxidant, anti-inflammatory and anticancer. However, as a result of very low aqueous solubility, it has a limited systemic absorption, following oral administration. METHODS Here, we prepared a stable lycopene-loaded solid lipid nanoparticles using Precirol® ATO5, Compritol 888 ATO and myristic...